Methods and compositions for inhibiting the nuclear factor κB pathway
AssigneesBen Gurion University of the Negev R&D Authority, Mor Research Applications Ltd.
InventorsAvi Golan, Jacob Gopas, Janet Ozer, Nadav Eisner, Adelbert Bacher, Wolfgang Eisenreich, Elena Ostrozhenkova, Hila Winer
Life of this patent
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Abstract
The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.
Claims17
A method for treating a subject afflicted with Hodgkin lymphoma, melanoma, or lung melanoma, comprising administering to said subject a) a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II);
- or a combination of the compound of Formula (I) and the compound of Formula (II)
- and;
- b) a composition comprising podophyllotoxin drug or platinum drug.
A method for treating cancer in a subject in need thereof, comprising administering to said subject a) a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract, comprising a compound of Formula (I) and a compound of Formula (II);
- or a combination of the compound of Formula (I) and the compound of Formula (II)
- and;
- b) a composition comprising podophyllotoxin drug or platinum drug.
A method for reducing or treating an inflammation disease in a subject in need thereof, comprising administering to said subject a compound of Formula (I) or (II), a composition comprising a a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II) ;
- or a combination of the compound of Formula (I) and the compound of Formula (II).
A method for treating a subject afflicted with Respiratory Syncytial Virus, comprising administering to said subject a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II);
- or a combination of the compound of Formula (I) and the compound of Formula (II).
A method for reducing a cytotoxic effect of a Respiratory Syncytial Virus in a subject, comprising administering to said subject a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II) (NUP),;
- or a combination of the compound of Formula (I) and the compound of Formula (II).
A method of reducing the contagiousness of a subject infected by a Respiratory Syncytial Virus, comprising administering to said subject a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II), or a combination of the compound of Formula (I) and the compound of Formula (II).
A method of reducing a cytotoxic effect of a Respiratory Syncytial Virus in a cell, comprising contacting said cell with a compound of Formula (I) or (II), a composition comprising a fraction of a Nymphaeaceae extract comprising a compound of Formula (I) and a compound of Formula (II) (NUP) ;
- or a combination of the compound of Formula (I) and the compound of Formula (II).
Dependencies are inferred from the claim text.