Nanoparticles for cytoplasmic drug delivery to cancer cells
AssigneeUniversity of Wyoming
InventorsMaciej Radosz, Peisheng Xu, Youqing Shen
Life of this patent
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Abstract
The invention is a nanoparticle that contains an anticancer drug that is released in cancer cells when administered to a subject. The nanoparticles have a core including the anticancer drug and polymer chains that are soluble at the pH of the cancer cell. The core is surrounded by a layer of polymer chains that are insoluble at the pH of healthy tissue but soluble at the pH of the cancer interstitium. An outside layer is made of water-soluble polymer chains to shield the nanoparticle from RES recognition and give the nanoparticle a long circulation time in the bloodstream of the subject. The outside layer may also include folic acid moieties that bind folic acid receptors on the surface of the cancer cell.
Claims7
A layered nanoparticle that, when administered to a subject, releases an anticancer drug within a cancer cell, the layered nanoparticle comprising:
- a block copolymer micelle, comprising poly[2-(N,N-dimethylamino)ethyl methacrylatel](PDMA) and poly[2-(N,N-diethylamino)ethyl methacrylatel](PDEA);
- (a) an outer layer of water-soluble polymer chain moieties;
- (b) an inner core layer containing the anticancer drug and polymer chains that dissolve in the cancer cell;
- and
- (c) an intermediate layer between the outer layer and the inner core layer, the intermediate layer being insoluble at a pH of about 7.4 but soluble at the pH of a cancer interstitium, wherein the pH of said cancer interstitium is between 5.6 and 6.4.
Dependencies are inferred from the claim text.