Micelles for the solubilization of gossypol
AssigneeWisconsin Alumni Research Foundation
InventorsGlen S. Kwon, Ho-Chul Shin, Hyunah Cho
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Abstract
The invention provides biocompatible micelles loaded with one or more active agents. The micelles can encapsulate anticancer drugs such as gossypol, and combinations of drugs, such as gossypol and paclitaxel, gossypol and 17-AAG, gossypol and cyclopamine, gossypol, paclitaxel, and 17-AAG, and gossypol, paclitaxel, and cyclopamine. The micelle compositions provide effective solubilization of difficult to solubilize drug combinations without the need for additional surfactants that can be toxic to patients. Thus, the invention provides stable and biocompatible drug formulations that improve bioavailability without causing toxicity.
Claims21
A micelle composition comprising an aqueous solvent system and drug-encapsulating micelles,
- wherein the micelles comprise a plurality of poloxamer polymers having an average molecular weight of about 1,000 g/mol to about 30,000 g/mol, the polymers form one or more micelles, the one or more micelles encapsulate a drug within their micelle structure, the drug is a gossypol compound that is not covalently bound to the polymer, and the diameter of the micelles is about 15 nm to about 150 nm.
A water soluble IV or IP formulation comprising gossypol loaded poloxamer 188 micelles and water, wherein the concentration of the gossypol in the formulation is at least about 3 mg/mL, and the formulation is free of organic solvents and surfactants.
Dependencies are inferred from the claim text.