Preparation of pharmaceutical compositions
OwnerAndrew James Elphick, John Staniforth +5inventors
InventorsAndrew James Elphick, John Staniforth, Dong Wang, David John Duncalf, Steven Paul Rannard, James Long, Alison Jayne Foster
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Abstract
A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
Claims5
A process for the production of a substantially solvent-free, water-soluble composition in powder form, the composition consisting of solid powder particles, wherein each particle consists of a water-soluble carrier material in which nanoparticles of a water-insoluble paracetamol or NSAID are dispersed, which process comprises the steps of:
- a) providing an emulsion consisting of:
- i) a solution of a water-insoluble paracetamol or NSAID in a water-immiscible solvent for the same, and
- ii) an aqueous solution of a water-soluble carrier material in water,
- b) spray-drying the emulsion to remove each solvent to thereby obtain said powdered composition of solid powder particles,
- wherein the particle size of the water-insoluble paracetamol or NSAID particles comprised in the solid powder particles obtained in step (b), as measured when said powdered composition is stirred using a magnetic bar into water whereupon the water-soluble carrier material dissolves and the water-insoluble paracetamol or NSAID particles disperse through the water, is below 1000 nm, and
- wherein the water-soluble carrier material consists of a polymer and/or a surfactant, said polymer being chosen from the group consisting of:
- polyethylene glycol, polyvinylpyrrolidone, poly(2-ethyl-2-oxazaline), polyvinyl alcohol, hydroxypropyl cellulose, hydroxypropyl methylcellulose and alginate.
Dependencies are inferred from the claim text.