Regulated delivery systems for inner ear drug application and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsBert W. O'Malley, Daqing Li
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Abstract
The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention relates to regulating drug delivery by the use of chitosan based matrices together with chitosanases.
Claims29
A system for controlled release delivery comprising:
- (i) a chitosan glycerophosphate (CGP) hydrogel comprising at least one agent effective in the treatment of otorhinolaryngology-associated pathology, or Head and Neck associated pathology;
- and
- (ii) a chitosanase present in an amount effective to dissolve the CGP hydrogel and thereby release the agent associated with the CGP hydrogel.
A method for treating an inner ear disease, comprising the steps of:
- (i) administering to a subject in need thereof a chitosan glycerophosphate (CGP) hydrogel comprising at least one agent effective in the treatment of an inner ear disease, and
- (ii) administering a chitosanase to the inner ear of the subject, wherein the administration of said chitosanase dissolves the CGP hydrogel and releases the agent associated with said CGP hydrogel.
A method for regulating the treatment of an inner ear disease, comprising the steps of:
- (i) administering to a subject in need thereof a chitosan glycerophosphate (CGP) hydrogel comprising at least one agent effective in the treatment of an inner ear disease, and
- (ii) administering a chitosanase to the inner ear of the subject (e.g., by applying to the round window membrane of the subject), wherein the administration of said chitosanase dissolves the CGP hydrogel and releases the agent associated with said CGP hydrogel.
A method for alleviating a drug induced ototoxicity, the method comprising:
- administering a chitosanase to an inner ear of a subject having a chitosan-glycerophosphate (CGP) hydrogel based drug delivery system applied to said inner ear, wherein the administration of said chitosanase dissolves said CGP hydrogel and releases said drug associated with said CGP hydrogel, thereby alleviating said drug induced ototoxicity.
A method for regulating a drug release from a chitosan-glycerophosphate (CGP) hydrogel in an inner ear of a subject, the method comprising:
- administering a chitosanase to said inner ear of said subject, wherein the administration of said chitosanase dissolves said CGP hydrogel and removes said drug associated with said CGP hydrogel from said inner ear, thereby regulating said drug release from said CGP hydrogel in said inner ear of said subject.
Dependencies are inferred from the claim text.