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US 8,945,622 B2Granted
Sustained release composition of therapeutic agent
AssigneeCouncil of Scientific and Industrial Research
InventorsRamesh Muthusamy, Mohan Gopalkrishna Kulkarni
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Abstract
A pH dependent drug delivery system comprising a pH sensitive graft copolymer, a therapeutically active agent and other pharmaceutically acceptable ingredients. More specifically, a composition which is capable of suppressing the drug release in the acidic pH prevalent in the stomach and releasing the drug over an extended period of time at pH prevalent in the intestinal region.
Claims27
A sustained release composition for oral administration comprising:
- a. a graft copolymer which exhibits pH dependent behavior having the formula 1
- comprising:
- i. a backbone having the formula P [A(x)B(y)C(z)] comprising a diol (A), a dicarboxylic acid or acid anhydride (B) and a monomer containing pendent unsaturation (C) wherein (x)=39-46%, (y)=49-54% (z)=5-8% by mole;
- ii. a graft which is a polymer of the acidic monomer (D) which comprises ‘w’ weight percent of the total weight of the said graft copolymer such that ‘w’ is 34-55%;
- b. an orally ingestible therapeutically active agent;
- and
- c. an orally ingestible pharmaceutically acceptable ingredient to form an orally ingestible composition for sustained release of the orally ingestible therapeutically active agent in the gastrointestinal tract of a patient, wherein said orally ingestible composition is in the form of a tablet.
4 more elements
Dependencies are inferred from the claim text.