US 8,945,618 B2Granted

Intrabuccally rapidly disintegrating tablet and a production method of the tablets

AssigneeKyowa Hakko Kirin Co., Ltd.

InventorsMotohiro Ohta, Eiji Hayakawa, Kunio Ito, Sanji Tokuno, Kiyoshi Morimoto, Yasushi Watanabe

Life of this patent

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Abstract

An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

Claims12

Dependent claims

A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:

a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μm;
an active ingredient;
and
one or more disintegrants selected from the group consisting of crosspovidone, crosscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof, said method comprising the steps of:
(a) mixing a powder material comprising the sugar alcohol or saccharide, said active ingredient and said one or more disintegrants;
(b) granulating the mixture of step (a), thereby producing granulated material having a predetermined particle size;
and
(c) compressing the granulated mixture into an intrabuccally rapidly disintegrating tablet.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/209,560Filed 13 Mar 2014 · continuation
Priority: 20 Jun 2003
Published: US 2014/0193496 A110 Jul 2014
Granted: 3 Feb 2015
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 9/2095
Pills, tablets, discs, rods: tabletting processes
A61J 3/10
Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms: into the form of…
A61K 9/0056
Mouth and digestive tract, i.e. intraoral and peroral administration: mouth soluble or dispersible forms; Suckable, eatable, chewable coherent…
A61K 9/2018
Organic compounds, e.g. phospholipids, fats: sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Family

PCT/JP97/02032Parent of this continuation-in-part · filed 12 Jun 1997
Application10/356,641Parent of this division · filed 20 Jun 2003
Application13/282,271Parent of this continuation · filed 26 Oct 2011
US 8,071,128 B2Parent of this division · filed 6 Dec 2011
Application13/744,179Parent of this continuation · filed 17 Jan 2013
US 8,357,396 B2Parent of this continuation · filed 22 Jan 2013
US 2014/0193496 A1Pre-grant publication · published 10 Jul 2014
Application13/282,271Parent of this division
Application09/147,374Parent of this continuation-in-part
Application10/356,641Parent of this continuation-in-part
US 2001/0014340 A1Published application
US 2003/0215500 A1Published application
US 2012/0135076 A1Published application
US 2013/0281546 A1Published application
US 8,956,650 B2Related patent
US 8,945,618 B2This patent

From the US filing history. Foreign family members aren’t listed.