Artificial oxygen carriers and use thereof
AssigneeUniversitäT Duisburg-Essen
InventorsHerbert De Groot, Christian Mayer, Frank Petrat, Michael Kirsch
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Abstract
The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
Claims15
A capsule dispersion of artificial oxygen carriers for use as a blood substitute, wherein the dispersion contains capsules with reversible oxygen storage capacity, wherein the capsules comprise an oxygen-permeable capsule material that contains or encloses fluorinated hydrocarbons,
- wherein the capsule dispersion is storage stable and the capsules have a diameter in the range of 50 to 1,000 nm,
- wherein the oxygen-permeable capsule material comprises an oxygen-permeable organic polymer, wherein the polymer is selected from the group of poly(lactide-co-glycolides) and polyalkylcyanoacrylates and mixtures thereof
- wherein the oxygen-permeable capsule material contains no sulphide bridges and has a coherent structure,
- wherein the weight ratio of oxygen-permeable capsule material to fluorinated hydrocarbons in the capsules is in the range of from 75:25 to 10:90,
- wherein the fluorinated hydrocarbons have molecular weights in the range from 250 to 2000 g/mole and are in liquid form,
- wherein the dispersion contains the capsules in volume-related quantities from 1-70% by volume relative to the dispersion,
- wherein the dispersion is adjusted to a physiological pH value,
- wherein the dispersion has a specific viscosity η in the range from 0.1 to 1.8 relative to temperatures in the range from 10° C. to 40° C., and
- wherein the dispersion is an aqueous-based dispersion and contains water as the continuous phase in the form of a physiological and isotonic sodium chloride solution.
Dependencies are inferred from the claim text.