Thermosetting neutralized chitosan composition forming a hydrogel, lyophilizate, and processes for producing the same
AssigneeLaboratoire Medidom S.A.
InventorsYannic Schuetz, Virginie Caratti-Besson, Oliver Jordan, Robert Gurny
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Abstract
The aqueous thermosetting neutralized chitosan composition, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., comprises 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized with an hydroxylated base, and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and polyols derived from polyoses. Said composition is useful for the preparation of an injectable formulation.
Claims12
An aqueous thermosetting neutralized chitosan composition forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., said composition comprising 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized until a pH of 6.7-7.1, under a temperature lower than 5° C. with an hydroxylated base previously cooled to a temperature lower than 5° C., and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and sugar alcohols suitable for pharmaceutical use;
- wherein the said aqueous composition can be lyophilized into a powder which can be then rehydrated into an aqueous thermosetting composition which still forms a phosphate free, transparent hydrogel at a temperature greater than 5° C. after lyophilization and rehydration.
Dependencies are inferred from the claim text.