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US 8,945,599 B2Granted
Immobilized biologically active entities having a high degree of biological activity
AssigneeW. L. Gore & Associates, Inc.
InventorsRobert L. Cleek, Michael D. Daly, Krzysztof R. Pietrzak
Life of this patent
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Abstract
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
Claims46
A medical device comprising:
- a polymeric substrate material,
- a plurality of biologically active entities having heparin cofactor II binding activity covalently attached to at least a portion of said polymeric substrate material;
- and
- a biologically compatible composition combined with said plurality of biologically active entities,
- wherein said biologically active entities have a heparin cofactor II binding activity of at least 5 picomoles heparin cofactor II per square centimeter (pmol/cm2).
2 more elements
A medical device comprising:
- a polymeric substrate material,
- a first plurality of biologically active entities having heparin cofactor II binding activity and a second plurality of biologically active entities having anti-thrombin Ill binding activity covalently attached to at least a portion of said polymeric substrate material;
- and
- a biologically compatible composition combined with said first plurality of biologically active entities and said second plurality of biologically active entities,
- wherein said biologically active entities have a heparin cofactor II binding activity of at least 5 picomoles heparin cofactor II per square centimeter (pmol/cm2) and at least 5 picomoles anti-thrombin Ill per square centimeter.
2 more elements
Dependencies are inferred from the claim text.