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US 8,945,592 B2Granted
Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
AssigneeAcelRx Pharmaceuticals, Inc.
InventorsShamim Pushpala, Larry Hamel, Stelios Tzannis, Evangeline Cruz
Life of this patent
Estimating the term…
Abstract
Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.
Claims26
A packaged solid sufentanil drug dosage form comprising:
- (a) a solid sufentanil drug dosage form;
- (b) a primary package containing said solid sufentanil drug dosage form and an oxygen scavenger, wherein the percentage of sufentanil oxidative degradation products is minimized or eliminated in a solid sufentanil drug dosage form packaged with said oxygen scavenger relative to a solid sufentanil drug dosage form packaged in the absence of an oxygen scavenger.
A method for minimizing or eliminating oxidative degradation of a solid sufentanil drug dosage form comprising:
- (a) providing a solid sufentanil drug dosage form in a drug delivery dispenser;
- (b) further providing an oxygen scavenger;
- (c) placing said drug delivery dispenser and said oxygen scavenger in a primary package made of a substantially oxygen impermeable material, wherein the percentage of sufentanil oxidative degradation products is minimized or eliminated in said solid sufentanil drug dosage form packaged with said oxygen scavenger relative to a solid sufentanil drug dosage form packaged in the absence of an oxygen scavenger.
Dependencies are inferred from the claim text.