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US 8,945,590 B2Granted
Enhancement of an immune response by administration of a cationic lipid-DNA complex (CLDC)
AssigneeJuvaris BioTherapeutics, Inc.
InventorsJeffery Fairman, Marla Lay Vaughn
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Abstract
This invention relates to a method for vaccination which is effective for eliciting an enhanced antigen-specific immune response in a mammal, fish or bird. The method is particularly effective for protecting a mammal, fish or bird from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such a method.
Claims15
A method for eliciting an immune response in a mammal, fish or bird comprising:
- administering to a mammal, fish or bird a therapeutic dose of a cationic lipid DNA complex (CLDC);
- administering to a mammal, fish or bird a therapeutic dose of an adjuvanted or unadjuvanted vaccine comprising a protein, inactivated virus, split virion, or lipopolysaccharide;
- wherein said CLDC is administered via an intravenous, intraperitoneal, inhalation or in ovo route;
- wherein said vaccine is administered via an intravenous, subcutaneous, intramuscular, intranasal or in ovo route;
- and
- wherein said vaccine is administered concomitantly with or 0-7 days after said CLDC administration.
3 more elements
Dependencies are inferred from the claim text.