Immunogenic compositions for Streptococcus agalactiae
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsJohn Telford, Guido Grandi, Immaculada Margarit Y Ros, Domenico Maione
Life of this patent
Estimating the term…
Abstract
This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
Claims10
A composition comprising:
- (1) a Group B Streptococcus (GBS) antigen combination GBS, wherein the antigen combination consists of:
- a first isolated Group B Streptococcus (GBS) polypeptide antigen, wherein the first isolated GBS polypeptide antigen is a GBS 80 polypeptide antigen comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:6, or an isolated fragment thereof comprising at least seven consecutive amino acids of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, or SEQ ID NO:6;
- and
- a second isolated GBS polypeptide antigen, wherein the second isolated GBS polypeptide antigen is a GBS 322 polypeptide antigen comprising the amino acid sequence of SEQ ID NO:38 or an isolated fragment of thereof comprising at least seven consecutive amino acids of SEQ ID NO:38;
- and
- (2) adjuvant comprising a submicron oil-in-water emulsion of 5% squalene, 0.5% polyoxyethylene sorbitan monooleate, and 0.5% sorbitan trioleate.
A composition comprising:
- (1) a Group B Streptococcus (GBS) antigen combination, wherein the antigen combination consists of:
- a first isolated GBS polypeptide antigen comprising the amino acid sequence of SEQ ID NO:7;
- and
- a second isolated GBS polypeptide antigen comprising the amino acid sequence of SEQ ID NO:38;
- and
- (2) an adjuvant comprising a submicron oil-in-water emulsion of 5% squalene, 0.5% polyoxyethylene sorbitan monooleate, and 0.5% sorbitan trioleate.
Dependencies are inferred from the claim text.