Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
AssigneeAgensys, Inc.
InventorsAya Jakobovits, Robert Kendall Morrison, Arthur B. Raitano, Pia M. Challita-Eid, Juan J. Perez-Villar, Karen Jane Meyrick Morrison, Mary Faris, Wangmao Ge, Jean Gudas, Steven B. Kanner
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Abstract
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.
Claims16
An antibody drug conjugate, comprising:
- an antibody or antigen binding fragment thereof conjugated to a cytotoxic agent, wherein the antibody or antigen binding fragment thereof specifically binds to a protein consisting of the amino acid sequence of SEQ ID NO:
- 3, wherein the antibody specifically binds to the protein within amino acid residues 25-45 or 274-285 of SEQ ID NO:
- 3.
An isolated monoclonal antibody or antigen binding fragment thereof comprising an antigen binding site that specifically binds to amino acid residues 25-45 or 274-285 of SEQ ID NO:
- 3.
An isolated antibody-drug conjugate, comprising:
- an antibody or antigen binding fragment thereof conjugated to a cytotoxic agent, wherein the antibody or antigen binding fragment thereof specifically binds to a peptide consisting of amino acid residues 25-45 or 274-285 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.