Jagged-binding agents and uses thereof
AssigneeOncoMed Pharmaceuticals, Inc.
InventorsAustin L. Gurney, Timothy Charles Hoey, Aaron Ken Sato, Alexandra Lazetic, Zhimin Ji
Life of this patent
Estimating the term…
Abstract
Antibodies that specifically bind to an extracellular domain of human Jagged 1 or human Jagged2 and modulate Jagged activity, and methods of using said antibodies to inhibit tumor growth are disclosed. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an anti-Jagged antibody to a patient having a tumor or cancer.
Claims23
An isolated antibody that specifically binds to an extracellular domain of human Jagged, wherein the antibody comprises:
- (a) a heavy chain CDR1 comprising SYWIH (SEQ ID NO:9), a heavy chain CDR2 comprising RIYPGIGSTYYNEKFKD (SEQ ID NO:10), and a heavy chain CDR3 comprising NGGFFDY (SEQ ID NO:11);
- and a light chain CDR1 comprising RASESVDSYGNSFMH (SEQ ID NO:12), a light chain CDR2 comprising RASNLES (SEQ ID NO:13), and a light chain CDR3 comprising QQSNEDPWT (SEQ ID NO:14);
- (b) a heavy chain CDR1 comprising SYAMH (SEQ ID NO:23), a heavy chain CDR2 comprising VISYDGSNKYYADSVKG (SEQ ID NO:24), AIYPDSSNKYYADSVKG (SEQ ID NO:47), AISPEASNKYYADSVKG (SEQ ID NO:48), or AIYPASSNKYYADSVKG (SEQ ID NO:49), and a heavy chain CDR3 comprising DKYDIPDAFDI (SEQ ID NO:25);
- and a light chain CDR1 comprising RASQGISNDLA (SEQ ID NO:26), a light chain CDR2 comprising ATSTLQS (SEQ ID NO:27), and a light chain CDR3 comprising QQSYNAPI (SEQ ID NO:28);
- or
- (c) a heavy chain CDR1 comprising SSNWWS (SEQ ID NO:37), a heavy chain CDR2 comprising EIFHGENTNYNPSLKS (SEQ ID NO:38), and a heavy chain CDR3 comprising NPGIGAAKFDS (SEQ ID NO:39);
- and a light chain CDR1 comprising KSSQSLLHSDGKTYLY (SEQ ID NO:40), a light chain CDR2 comprising EVSNRFS (SEQ ID NO:41), and a light chain CDR3 comprising MQHIDFP (SEQ ID NO:42).
A monoclonal antibody produced by the hybridoma cell line 64M51 on deposit as ATCC Patent Deposit Designation PTA-10468.
An antibody encoded by the polynucleotide deposited with the ATCC as PTA-10470 or as PTA-10469.
A polypeptide comprising a sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:19, SEQ ID NO:21, SEQ ID NO:33, SEQ ID NO:35, SEQ ID NO:50, SEQ ID NO:51, and SEQ ID NO:52.
Dependencies are inferred from the claim text.