Anti-complement C1s antibodies
AssigneeTrue North Therapeutics, Inc.
InventorsPeter Van Vlasselaer, Graham Parry, Nancy E. Stagliano, Sandip Panicker
Life of this patent
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Abstract
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
Claims47
A container comprising a composition comprising a humanized antibody that binds complement C1s protein and comprises light chain complementarity determining regions (CDRs) of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8.
A lyophilized composition comprising a humanized antibody that binds complement C1s protein and comprises light chain complementarity determining regions (CDRs) of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8.
A composition comprising:
- a) a humanized antibody comprising:
- i) a light chain variable region comprising a complementarity-determining region (CDR) comprising a CDR-L1 having the amino acid sequence of SEQ ID NO:1, a CDR-L2 having the amino acid sequence of SEQ ID NO:2, a CDR-L3 having the amino acid sequence of SEQ ID NO:3;
- and
- ii) a heavy chain variable region comprising a CDR comprising a CDR-H1 having amino acid sequence SEQ ID NO:4, a CDR-H2 having amino acid sequence SEQ ID NO:5, and a CDR-H3 having amino acid sequence SEQ ID NO:6;
- and
- b) a pharmaceutically acceptable excipient.
A composition comprising:
- a) a humanized antibody that binds complement C1s protein and comprises light chain complementarity-determining regions (CDRs) of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8,
- wherein the humanized antibody comprises a humanized light chain framework region;
- and
- b) a pharmaceutically acceptable excipient.
A composition comprising:
- a) a humanized antibody that binds complement C1s protein and comprises light chain complementarity-determining regions (CDRs) of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8,
- wherein the humanized antibody comprises a humanized heavy chain framework region;
- and
- b) a pharmaceutically acceptable excipient.
A humanized antibody that binds complement C1s protein and comprises an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8 comprising one or more humanized heavy chain framework regions.
Dependencies are inferred from the claim text.