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US 8,945,557 B2Granted
Use of immunesuppressant receptor
AssigneeOno Pharmaceutical Co., Ltd.
InventorsTomoyuki Odani, Hideaki Tada, Kimiho Yamada
Life of this patent
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Abstract
The present invention relates to use of an antagonist of BIR1 (B cell immunoglobulin receptor 1) related to the present invention, a method for screening the antagonist, in addition to subtype polypeptides of BIR1, the polynucleotide encoding them and antibodies for the polypeptides. BIR1 functions as an immunosuppressive receptor, and the antagonist of BIR1 has immunopotentive activity, which is able to use for preventing and/or treating a cancer, an immunodeficiency disease or an infectious disease.
Claims11
A method for potentiating an immune response comprising:
- administering to a subject in need thereof an effective amount of an antagonist of a protein, said protein having the amino acid sequence of any one of SEQ ID NOs:
- 1 to 6, wherein the antagonist is
- an isolated monoclonal antibody or fragment thereof that specifically binds to a protein having the amino acid sequence of any one of SEQ ID NOs:
- 1 to 6.
1 more element
Dependencies are inferred from the claim text.