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US 8,945,556 B2Granted
RAF gene fusions
AssigneeThe Regents of the University of Michigan
InventorsArul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Abstract
The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.
Claims11
A composition comprising at least one of the following:
- (a) an oligonucleotide probe that hybridizes to a junction of a chimeric genomic DNA or a chimeric mRNA, wherein a 5′ portion of the chimeric genomic DNA or the chimeric mRNA is from an AGTRAP gene and a 3′ portion of the chimeric genomic DNA or the chimeric mRNA is from a RAF family member gene;
- (b) an antibody specific for a fusion protein having an amino-terminal portion encoded by an angiotensin II, type I receptor-associated protein (AGTRAP) gene and a carboxy-terminal portion encoded by a kinase domain of a RAF family member gene.
Dependencies are inferred from the claim text.