Inotropic antibodies and therapeutic uses thereof
OwnerKai Yuan Xuinventor
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Abstract
Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
Claims4
A method of producing a positive inotropic effect in a mammalian host comprising administering to said mammalian host a therapeutically effective amount of an antibody which binds to a peptide consisting of the amino acid sequence as set forth in DVEDSYGQQWTYEQR (SEQ ID NO:2), wherein said antibody binds (Na++K+)-ATPase to increase intracellular calcium, wherein the antibody enhances the velocity of shortening of the ventricular myocyte and increases the force of contraction of the heart cells.
Dependencies are inferred from the claim text.