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US 8,945,551 B2Granted
Biopolymer hybrid gel-depot delivery system
AssigneePolymers Crc Ltd.
InventorsDavid Edward Mainwaring, Mohammad Al Kobaisi, Brendon Yew Loong Chua, David Charles Jackson
Life of this patent
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Abstract
The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based gel-depots which include a biologically active agent, and uses of such biopolymer gel-depots in therapy. The biopolymer-gel based depot systems comprise a biocompatible polyaminosaccharide and/or protein; a biocompatible phosphate and/or sulphonamide compound; a biologically active agent; an aqueous insoluble alkaline earth metal phosphate; and a biocompatible glycan and/or proteoglycan.
Claims24
A prolonged release and/or controlled release delivery system for delivery of a biologically active agent, the system comprising:
- (i) a first component comprising a biocompatible polyaminosaccharide;
- and
- (ii) a second component comprising a biocompatible phosphate or biocompatible sulphonamide compound capable of crosslinking with the first component,
- wherein the delivery system further comprises the biologically active agent, an aqueous insoluble alkaline earth metal phosphate, and a biocompatible glycan;
- wherein each of the biologically active agent, aqueous insoluble earth metal phosphate and biocompatible glycan is present in either of the first and/or second components;
- and
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184;
- and
- whereby the first and second components of the system are physically isolated and, when in use, combining of the first and second components promotes crosslinking and results in the formation of a biopolymer hybrid gel-depot including the biological active agent.
9 more elements
A method of forming a prolonged release and/or controlled release biopolymer hybrid gel-depot including a biologically active agent, said method comprising:
- (i) providing a first component comprising a biocompatible polyaminosaccharide, and a second component comprising a biocompatible phosphate and/or sulphonamide compound capable of crosslinking with the first component,
- (a) wherein the first and/or second component further comprises the biologically active agent;
- and
- (b) wherein the first and/or second component also comprises:
- (i) an aqueous insoluble alkaline earth metal phosphate;
- and/or
- (ii) a biocompatible glycan and/or proteoglycan
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184;
- and
- (ii) combining the first and second components for a time and under conditions to promote crosslinking and to form a biopolymer hybrid gel-depot including the biologically active agent.
10 more elements
A biopolymer hybrid gel-depot comprising:
- (i) a biocompatible polyaminosaccharide;
- (ii) a biocompatible phosphate and/or sulphonamide substantially crosslinked to (i);
- (iii) an aqueous insoluble alkaline earth metal phosphate;
- (iv) a biocompatible proteoglycan;
- and
- (v) a biologically active agent,
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184.
7 more elements
A biopolymer hybrid gel-depot comprising:
- (i) chitosan (or a suitably functionalised derivative thereof);
- (ii) tripolyphosphate substantially crosslinked to (i);
- (iii) hydroxyapatite;
- (iv) chondroitin sulphate;
- and
- (v) a biologically active agent
- wherein the % wt/wt ratio ranges of:
- the chitosan to the hydroxyapatite is from about 40:1 to about 10:1;
- and
- the chitosan to the tripolyphosphate is from about 100:74 to about 100:184.
7 more elements
A method of delivering a biologically active agent to a subject including the step of administering:
- (i) a first component comprising a biocompatible polyaminosaccharide;
- and
- (ii) a second component comprising a biocompatible phosphate and/or sulphonamide compound capable of crosslinking with the first component,
- wherein
- (a) the first and/or second component further comprises the biologically active agent;
- and
- (b) the first and/or second compounds also comprises:
- an aqueous insoluble alkaline earth metal phosphate;
- and/or
- (ii) a biocompatible glycan and/or proteoglycan;
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate and/or biocompatible sulphonamide is from about 100:74 to about 100:184;
- and
- whereby the first and second components are simultaneously or sequentially injected at the same site.
13 more elements
A method of delivering a biologically active agent to a subject including the step of implanting a biopolymer hybrid gel-depot comprising:
- (i) a biocompatible polyaminosaccharide;
- (ii) a biocompatible phosphate and/or sulphonamide substantially crosslinked to (i);
- (iii) an aqueous insoluble alkaline earth metal phosphate;
- (iv) a biocompatible glycan and/or proteoglycan;
- and
- (v) a biologically active agent
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate and/or biocompatible sulphonamide is from about 100:74 to about 100:184.
7 more elements
A prolonged release and/or controlled release delivery system for delivery of a biologically active agent, the system comprising:
- (i) a first component comprising a biocompatible polyaminosaccharide, the biologically active agent, and an aqueous insoluble alkaline earth metal phosphate;
- and
- (ii) a second component comprising a biocompatible phosphate or biocompatible sulphonamide compound capable of crosslinking with the first component, and a biocompatible glycan;
- wherein the % wt/wt ratio ranges of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184;
- and
- whereby the first and second components of the system are physically isolated and, when in use, combining of the first and second components promotes crosslinking and results in the formation of a biopolymer hybrid gel-depot including the biological active agent.
6 more elements
A prolonged release and/or controlled release delivery system for delivery of a biologically active agent to a subject, the system comprising:
- (i) a first component comprising a biocompatible polyaminosaccharide;
- and
- (ii) a second component comprising a biocompatible phosphate or biocompatible sulphonamide compound capable of crosslinking with the first component;
- wherein the delivery system further comprises the biologically active agent, an aqueous insoluble alkaline earth metal phosphate and a biocompatible glycan;
- wherein each of the biologically active agent, aqueous insoluble earth metal phosphate and biocompatible glycan is present in either of the first and/or second components;
- and
- wherein the % wt/wt ratio range of:
- the biocompatible polyaminosaccharide to the aqueous insoluble alkaline earth metal phosphate is from about 40:1 to about 10:1;
- and
- the biocompatible polyaminosaccharide to the biocompatible phosphate or biocompatible sulphonamide is from about 100:74 to about 100:184;
- and
- whereby the first and second components of the system are physically isolated and, when injected into the subject result in the formation of a biopolymer hybrid gel-depot including the biological active agent in the subject, wherein the biopolymer hybrid gel-depot including the biological active agent has a compressive modulus in the range of about 100 kPa to 500 kPa.
9 more elements
Dependencies are inferred from the claim text.