Anti-IL12Rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders

An isolated antibody or a protein with an antigen-binding portion of an antibody, comprising

• (a) a variable heavy chain amino acid sequence comprising HCDR1 of SEQ ID NO:7, HCDR2 of SEQ ID NO:8, HCDR3 of SEQ ID NO:9 and a variable light chain amino acid sequence comprising LCDR1 of SEQ ID NO:10, LCDR2 of SEQ ID NO:11 and LCDR3 of SEQ ID NO:12;
• (b) a variable heavy chain amino acid sequence comprising HCDR1 of SEQ ID NO:13, HCDR2 of SEQ ID NO:14, HCDR3 of SEQ ID NO:15 and a variable light chain amino acid sequence comprising LCDR1 of SEQ ID NO:16, LCDR2 of SEQ ID NO:17 and LCDR3 of SEQ ID NO:18;
• or
• (c) a variable heavy chain amino acid sequence comprising HCDR1 of SEQ ID NO:19, HCDR2 of SEQ ID NO:20, HCDR3 of SEQ ID NO:21 and a variable light chain amino acid sequence comprising LCDR1 of SEQ ID NO:22, LCDR2 of SEQ ID NO:23 and LCDR3 of SEQ ID NO:24;
• wherein said antibody or protein binds to the IL12Rβ1 polypeptide of SEQ ID NO:89.