US 8,945,547 B2 · Notch1 receptor antibodies and methods of treatment

Abstract

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

Claims19

Dependent claims

An isolated antibody that specifically binds human NOTCH1, which comprises:

(a) a heavy chain variable region having at least 90% sequence identity to SEQ ID NO:14 or SEQ ID NO:24;
and
(b) a light chain variable region having at least 90% sequence identity to SEQ ID NO:8, SEQ ID NO:28, or SEQ ID NO:32.

Dependencies are inferred from the claim text.

Facts

Application

13/826,284Filed 14 Mar 2013 · continuation

Priority

8 Jul 2008

Published

US 2013/0280277 A124 Oct 2013

Granted

3 Feb 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification40 codes

C07K 16/22
Against material from animals or humans: against growth factors ; against growth regulators
A61K 31/337
Having oxygen as the only ring hetero atom, e.g. fungichromin: having four-membered rings, e.g. taxol
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens

Family

Application61/079,095Us provisional application · filed 8 Jul 2008

Application61/112,699Us provisional application · filed 7 Nov 2008

Application61/112,701Us provisional application · filed 7 Nov 2008

PCT/US2009/003995Parent of this continuation · filed 8 Jul 2009

US 8,435,513 B2Parent of this continuation · filed 7 May 2013

US 2013/0280277 A1Pre-grant publication · published 24 Oct 2013

Application13/003,013Parent of this continuation

US 2011/0311552 A1Published application

US 8,945,547 B2This patent

From the US filing history. Foreign family members aren’t listed.

Notch1 receptor antibodies and methods of treatment

Life of this patent

Notch1 receptor antibodies and methods of treatment

Life of this patent

Abstract

Claims19