Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsLeslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Jeffry D. Watkins, Cheryl L. Quinn, Wing-Sze Lo, Zhiwen Xu, John D. Mendlein
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Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims12
A therapeutic composition, comprising an isolated phenylalanyl-beta-tRNA synthetase (PheRS) polypeptide of about 100 to about 130 amino acids in length and comprising an amino acid sequence that is at least 95% identical to 100 or more contiguous amino acids of SEQ ID NO:53, wherein the polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein.
Dependencies are inferred from the claim text.