Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof
AssigneeExOxEmis, Inc.
InventorsSophie Becquerelle, William Haag, Obsidiana Abril-Horpel, Shri Valvani
Life of this patent
Estimating the term…
Abstract
Methods and compositions are provided for inhibiting the growth of susceptible microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with myeloperoxidase and at least two activity enhancing agent amino acids.
Claims21
A composition for inhibiting the growth of susceptible microorganisms comprising myeloperoxidase, glucose oxidase, sodium chloride, polysorbate 80, phosphate buffer, and two amino acids, wherein one of the two amino acids is glycine, and the other of the two amino acids is selected from the group consisting of D-isoleucine;
- L-isoleucine;
- L-tyrosine;
- and L-valine;
- and wherein the two amino acids work in combination to enhance the microbicidal activity of the myeloperoxidase.
A composition for killing or inhibiting the growth of susceptible microorganisms, wherein the composition consists of myeloperoxidase, glycine, L-alanine, L-proline, glucose oxidase, sodium chloride, polysorbate-80, sodium phosphate buffer, and water, wherein the glycine, L-alanine, and L-proline in the composition work in combination to enhance the microbicidal activity of the myeloperoxidase.
A binary combination, comprising:
- (a) a first composition comprising myeloperoxidase, glucose oxidase, sodium chloride, polysorbate-80, phosphate buffer, water and two amino acids, wherein one of the two amino acids is glycine, and the other of the two amino acids is selected from the group consisting of D-isoleucine;
- L-isoleucine;
- L-tyrosine;
- and L-valine;
- and wherein the two amino acids work in combination to enhance the microbicidal activity of the myeloperoxidase;
- and
- (b) a second composition comprising glucose and water.
A binary combination for killing or inhibiting the growth of susceptible microorganisms, consisting of:
- (a) a first composition consisting of myeloperoxidase, glycine, L-alanine, L-proline, glucose oxidase, sodium chloride, polysorbate-80, sodium phosphate buffer, and water, wherein the glycine, L-alanine, and L-proline in the composition work in combination to enhance the microbicidal activity of the myeloperoxidase;
- and
- (b) a second composition comprising glucose and water.
Dependencies are inferred from the claim text.