Bone substitute compositions, methods of preparation and clinical applications
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPrashant Nagesh Kumta, Charles S. Sfeir, Abhijit Roy
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Abstract
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer.
Claims16
A method of repairing or replacing defective native bone tissue, comprising:
- preparing a bone substitute composition, comprising:
- combining calcium phosphate, acidic calcium salt, basic calcium salt, material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate and mixtures thereof, and porogen to form a powder component;
- and
- mixing the powder component with a liquid colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt;
- obtaining a patient having defective native bone tissue;
- and
- administering in vivo the bone substitute composition in a form selected from the group consisting of paste, putty and cement, into the patient at the site of the defective native bone tissue.
A method for delivering cellular and biological material to a target site in a patient, comprising:
- preparing a bone substitute composition, comprising:
- combining calcium phosphate, acidic calcium salt, basic calcium salt, material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate and mixtures thereof, and porogen to form a powder component;
- and
- mixing the powder component with a liquid colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt, the colloidal mixture being complexed with at least one of a compound selected from the group consisting of protein, peptide, DNA, drug, stem cell, normal cell, and combinations thereof;
- obtaining a patient having defective native bone tissue;
- and
- administering in vivo the bone substitute composition in a form selected from the group consisting of paste, putty and cement, into the patient at the target site.
A bone substitute composition, comprising:
- a powder component, comprising:
- calcium phosphate;
- acidic calcium salt;
- basic calcium salt;
- material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate, and mixtures thereof;
- and
- porogen;
- and
- a liquid component, comprising:
- a colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt, the nanoparticulate calcium phosphate formed by reaction of calcium and non-acidic ionic phosphate in the presence of hydroxyl ions,
- wherein the composition is effective to regenerate bone in the absence of a biological growth component.
A bone substitute composition, comprising:
- a powder component, comprising:
- calcium phosphate;
- acidic calcium salt;
- basic calcium salt;
- material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate, and mixtures thereof;
- and
- porogen;
- and
- a liquid component, comprising:
- a colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt, the nanoparticulate calcium phosphate formed by reaction of calcium and non-acidic ionic phosphate in the presence of hydroxyl ions,
- wherein the porogen is present in an amount such that the composition has a porosity of about 80% or greater.
Dependencies are inferred from the claim text.