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US 8,945,531 B2Granted
Recombinant herpes virus and pharmaceutical composition containing the same
AssigneeThe University of Tokyo
InventorsTomoki Todo, Hiroshi Fukuhara
Life of this patent
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Abstract
A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.
Claims12
A recombinant herpes simplex virus in which the endogenous large subunit of ribonucleotide reductase (ICP6) gene is deleted or inactivated, comprising,
- on the genome of the virus, an expression cassette constructed to express an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter.
Dependencies are inferred from the claim text.