Back to results
US 8,945,512 B2Granted
Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications
AssigneeBracco Imaging S.P.A.
InventorsSilvio Aime, Enzo Terreno, Daniela Delli Castelli, Giovanni Battista Giovenzana
Life of this patent
Estimating the term…
Abstract
Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
Claims5
A method of imaging a subject comprising, administering to the subject a paramagnetic CEST agent comprising,
- a substrate molecule (SH) comprising at least one mobile proton in exchange with bulk water bound by electrostatic interactions having a thermodynamic constant of association Ka greater than 10 to a paramagnetic chelate complex (SR) of a metal ion selected from the group consisting of:
- iron (II) (high-spin configuration), iron (III), cobalt (II), rhodium (II), copper (II), nickel (II), cerium (III), praseodymium (III), neodymium (III), dysprosium (III), erbium (III), terbium (III), holmium (III), thulium (III), ytterbium (III) and europium (III);
- applying an if pulse sufficient to saturate the resonance of the at least one mobile proton shifted from the bulk water as a result of said electrostatic interaction to create a saturated magnetization that is transferred to the bulk water through chemical exchange, and
- imaging the subject using a CEST-based MRI procedure.
1 more element
Dependencies are inferred from the claim text.