In-situ formable nucleus pulposus implant with water absorption and swelling capability
AssigneeWarsaw Orthopedic, Inc.
InventorHai H. Trieu
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Abstract
Embodiments of the invention relate to a curable nucleus pulposus implant having water absorption and swelling capabilities, compositions for producing the curable nucleus pulposus implants, and methods of using the curable nucleus pulposus implants. The curable nucleus pulposus implant can be created from a polymer blend composition comprising a ratio of a curable material and at least one hydrophilic polymer. The resulting polymer blend composition may be used to generate curable nucleus pulposus implants to treat a number of disease and/or disorders, such as herniated discs. The curable nucleus pulposus implants may further contain polyelectrolytes and elastomer compounds, as well as pharmacological and biological agents.
Claims34
An in-situ three-part formable nucleus pulposus implant composition, comprising a first part, a second part and a third part that when mixed together in-situ provides a cured polyurethane implant;
- said first part comprising an in-situ curable polymerizable material comprising 2,4′-diphenylmethane diisocyanate, 4,4′-diphenylmethane diisocyanate, and toluene diisocyanate;
- said second part comprising at least one hydrophilic polymer, wherein the polymerizable material and the at least one hydrophilic polymer are present in a ratio of about 1:1 to about 19:1, respectively, the hydrophilic polymer comprising at least one of polyacrylic acid, polyacrylamides, or poly(N-vinyl-2-pyrrolidone),
- said third part comprising at least one therapeutic agent selected the group consisting of antibiotics, analgesics, anti-inflammatory drugs, steroids, anti-viral and anti-retroviral compounds, therapeutic proteins, therapeutic peptides, and therapeutic nucleic acids;
- and
- wherein said in-situ three-part formable composition polymerizes inside a partially evacuated intervertebral disc space to form a polymerized implant.
Dependencies are inferred from the claim text.