Ligament and tendon replacement constructs and methods for production and use thereof

A ligament or tendon scaffold comprising:

• a three-dimensional braid prepared by a three dimensional braiding technique,
• said braid comprising biodegradable polymer fibers,
• wherein said braid terminates in three-dimensional, braided first and second attachment ends and said braid includes a three-dimensional, braided middle region that differs from both of said attachment ends in size, braiding angle, porosity, and mechanical strength to facilitate a differential cellular response in said middle region as compared with said first and second attachment ends.