Otic formulations, methods and devices

A formulation for treating ear infection, comprising:

• a) active ingredients for treating fungal and bacterial infection comprising:
• i) about 0.3% by weight of ciprofloxacin, ofloxacin, or the combination thereof;
• ii) about 1% by weight of a clotrimazole, itraconazole, or the combination thereof;
• iii) about 1% by weight of a tolnaftate;
• iv) about 0.1% by weight of a dexamethasone;
• and
• v) about 100,000 unit/ml of a nystatin;
• b) about 10-25% of wax;
• and
• c) about 75-90% of mineral oil;
• d) wherein after applying to the ear canal of a mammal having said ear infection, said formulation remains in the ear canal and has a viscosity of about 62,000 cPs at 37° C.;
• and
• e) wherein upon introduction into the ear canal said formulation remains in the ear canal releasing said active ingredients for 2-7 days, and thereafter is not found in said ear, and
• f) wherein said formulation is for single treatment and has a cure rate of at least 95%.

A formulation for treating ear infection, comprising

• a) one or more antifungal agents;
• b) one or more anti-bacterial agents;
• c) one or more anti-inflammatory agents;
• and
• d) a carrier having 40,000-80,000 cPs at 37° C., wherein said carrier retains said active ingredients in an ear for 2-7 days and then egresses or is absorbed,
• wherein said formulation is for single treatment and has a cure rate of at least 95%.

An otic formulation, selected from:

• 0.01% fluoroquinolone, 0.1% triazole antifungal, 0.1% thiocarbamate,
• 0.01% corticosteroid, and 50,000 unit/ml of a polyene antifungal plus thickener and mineral oil;
• 1% fluoroquinolone, 2% triazole antifungal, 2% thiocarbamate, 1% by weight of a corticosteroid, and 200,000 unit/ml of a polyene antifungal in thickener, and mineral oil;
• 0.3% ciprofloxacin, 1% clotrimazole, 1% tolnaftate, 0.1% dexamethasone;
• and 100,000 unit/ml of a nystatin in an otic carrier that is 10-25% wax, and 75-90% of mineral oil;
• 0.3% ciprofloxacin, 1% ofloxacin, 1% itraconazole, 1% tolnaftate 0.1% dexamethasone, and 100,000 unit/ml of a nystatin in 10-25% wax and 75-90% mineral oil;
• 0.3% ciprofloxacin, 1% ofloxacin, 1% itraconazole, 1% tolnaftate, 0.1% dexamethasone, and 100,000 unit/ml of nystatin in 55-60% PCCA Plasticized™ and 40-45% mineral oil;
• 0.3% ciprofloxacin, 1% ofloxacin, 1% clotrimazole, 1% tolnaftate 0.1% dexamethasone, and 100,000 unit/ml of a nystatin in 55-60% PCCA Plasticized™ and 40-45% mineral oil;
• 0.3% ciprofloxacin ofloxacin or the combination thereof, 1% by weight of a clotrimazole, itraconazole, or the combination thereof;
• 1% by weight of a tolnaftate;
• 0.1% by weight of a dexamethasone;
• and 100,000 unit/ml of a nystatin in an otic carrier that is 10-25% of wax;
• and 75-90% of mineral oil;
• 0.3% ciprofloxacin, 100,000 u/ml Nystatin, 1% Itraconazole, 0.1% Dexamethasone and 1% Tolnaftate in 18% candela wax and 82% mineral oil;
• 0.3% ciprofloxacin;
• 100,000 u/ml Nystatin, 1% clotrimazole, 0.1% Dexamethasone, 1% Tolnaftate (1%) in 80% mineral oil and 20% bees wax;
• 0.3% ciprofloxacin;
• 100,000 u/ml Nystatin, 1% clotrimazole, 0.1% Dexamethasone, 1% Tolnaftate in 82% mineral oil and 18% paraffin;
• 0.3% ciprofloxacin;
• 100,000 u/ml Nystatin, 1% clotrimazole, 0.1% Dexamethasone, 1% Tolnaftate in mineral oil and wax;
• 0.3% ciprofloxacin;
• 1% clotrimazole, 0.1% Dexamethasone in 82% mineral oil and 18% paraffin;
• 0.5% ciprofloxacin;
• 2% clotrimazole, 0.2% Dexamethasone in 82% mineral oil and 18% paraffin;
• 0.6% ciprofloxacin;
• 2% clotrimazole, 0.2% Dexamethasone in 82% mineral oil and 18% paraffin;
• 0.3% ciprofloxacin, 100,000 u/ml Nystatin, 0.1% dexamethasone;
• 0.3% ciprofloxacin, 1% voriconazole, 0.1% dexamethasone;
• 0.3% ciprofloxacin, 1% amphotericin B, 0.1% dexamethasone;
• 0.3% levofloxacin, 1% amphotericin B, 0.1% dexamethasone;
• 0.3% levofloxacin, 1% voriconazole, 0.1% dexamethasone;
• 0.3% ciprofloxacin, 1% ketoconazole, 0.1% dexamethasone;
• and
• 0.3% Ciprofloxacin;
• 1% clotrimazole, 0.1% hydrocortisone.