A method of making a retractable syringe including the step of inserting a needle retainer into a barrel of the retractable syringe, the needle retainer comprising a plurality of centering bosses that facilitate self-centering of the needle retainer in the barrel, providing a retractable needle having a cannula extending through a needle body, the needle body having one or more fluid channels, inserting the retractable needle into the barrel, providing a plunger including a plunger outer, one or more locking members, and a plunger member, the plunger member including a unitary plunger seal that includes a needle-engaging recess and one or more fluid conduits in said needle-engaging recess that are capable of directing fluid to said one or more fluid channels in said retractable needle, a first of said one or more locking members being mounted to the plunger outer and capable of preventing or impeding further movement of said plunger member relative to said plunger outer and/or said barrel after needle retraction, and inserting at least a portion of the plunger into the barrel so that the unitary plunger seal seals against an inner wall of said barrel.