Devices, systems, and methods for organ retroperfusion

A method of organ perfusion, the method comprising the steps of:

• positioning at least a portion of an arterial tube of a perfusion system within an artery of a patient, the arterial tube configured to permit arterial blood having a first pressure to flow therethrough;
• positioning at least a portion of a first catheter of the perfusion system into a vein of the patient at or near a target organ and directly connecting the first catheter to the arterial tube, the first catheter configured to receive some or all of the arterial blood from the arterial tube;
• and
• operating a first flow regulator of the perfusion system to regulate the pressure of the arterial blood flowing into the vein, while a heart of the patient is pumping blood, so that some or all of the arterial blood flowing through the arterial tube is provided into the vein at a second pressure to treat a condition or disease of the target organ, wherein said arterial blood flows through the arterial tube due to pumping of the patient's heart and without the use of a secondary pump;
• and
• wherein the method further comprises the step of modifying the pressure of the arterial blood flowing into the vein to achieve arterialization over time.

A method of organ perfusion, the method comprising the steps of:

• positioning at least a portion of an arterial tube of a perfusion system within an artery of a patient, the arterial tube configured to permit arterial blood having a pressure to flow therethrough;
• positioning at least a portion of a first catheter of the perfusion system into a vein of the patient at or near a target organ and directly connecting the first catheter to the arterial tube, the first catheter configured to receive some or all of the arterial blood from the arterial tube;
• and
• inflating an expandable balloon positioned along the portion of the first catheter positioned in the vein to secure the portion of the first catheter within the vein;
• and
• operating a first flow regulator of the perfusion system to regulate the pressure of the arterial blood flowing into the vein, while a heart of the patient is pumping blood, so that some or all of the arterial blood flowing through the arterial tube is provided into the vein to treat a condition or disease of the target organ, wherein said arterial blood flows through the arterial tube due to pumping of the patient's heart and without the use of a secondary pump;
• wherein the step of positioning at least part of the arterial tube is performed by positioning at least part of the arterial tube within an artery selected from the group consisting of a femoral artery, an internal femoral artery, an iliac artery, an axillary artery, a brachial artery, a subclavian artery, an epigastric artery, an external carotid artery;
• and
• wherein the step of operating a first flow regulator is performed to permit blood flow from the cannula to the vein to treat a condition selected from the group consisting of a diabetic condition, a kidney condition, an intestinal condition, a spinal condition, and a penile condition;
• and
• wherein the method further comprises the step of modifying the pressure of the arterial blood flowing into the vein to achieve arterialization over time.