Methods and apparatus for control of non-invasive parameter measurements

A non-transitory computer readable apparatus comprising a plurality of instructions which are configured to, when executed by a processor:

• cause optimal coupling to be established between an applanation and/or positioning mechanism having at least a sensor associated therewith and a tissue surface that overlies a blood vessel of interest;
• cause said sensor to collect hemodynamic data, said hemodynamic data comprising one or more parameters;
• evaluate said collected hemodynamic data to identify an occurrence of a transient event which affects said optimal coupling via analysis of changes in said one or more parameters;
• and
• when said changes to said one or more parameters meet one or more criterion:
• cause said sensor to cease collection of said data;
• cause said applanation and/or positioning mechanism to initiate a pressure sweep to re-establish said optimal coupling;
• and
• cause said sensor to resume collection of said hemodynamic data upon termination of said transient event and said re-establishment of said optimal coupling.

A non-transitory computer readable apparatus comprising a plurality of instructions which are configured to, when executed by a processor:

• establish an optimal coupling between a sensor and a tissue surface that at least partially overlies a blood vessel of interest;
• generate a waveform related to a plurality of hemodynamic data collected by said sensor;
• detect a transient event which affects said coupling between said sensor and said tissue surface that at least partially overlies said blood vessel of interest;
• upon detection of said transient event:
• introduce changes in said waveform via an applanation and/or positioning mechanism, said changes being associated with a modulation of a compression applied to said tissue surface via a pseudo-random binary sequence;
• anticipate said changes in said waveform and correct at least portions of said waveform by use of a pressure correction offset to restore said waveform to a shape that is equivalent to an un-modulated waveform;
• temporally cease collection of and/or use of said hemodynamic data during a period which said hemodynamic data is unreliable;
• and
• resume at least one of collection and/or use of said hemodynamic data upon termination of said transient event.

A method of operating a hemodynamic assessment apparatus comprising an applanation and/or positioning mechanism, a sensor, and computerized logic configured to identify a transient event affecting a coupling between said sensor and a tissue surface overlying a blood vessel of interest, said method comprising:

• establishing an optimal coupling via said applanation and/or positioning mechanism;
• collecting hemodynamic data using said sensor, said hemodynamic data comprising one or more parameters;
• detecting, using said computerized logic, an occurrence of said transient event affecting said optimal coupling by determining that changes in said one or more parameters of said collected hemodynamic data meet one or more criterion;
• and
• during said transient event:
• ceasing collection of said data by said sensor;
• and
• initiating a pressure sweep to re-establish said optimal coupling via said applanation and/or positioning mechanism;
• and
• upon termination of said transient event, said sensor resuming collection of said hemodynamic data and said re-establishing said optimal coupling.