Controlled activation ingestible identifier
AssigneeProteus Digital Health, Inc.
InventorsHooman Hafezi, Timothy Robertson, Olivier Colliou, Mark Zdeblick
Life of this patent
Estimating the term…
Abstract
Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
Claims21
A pharmaceutical composition comprising:
- a pharmaceutical active agent;
- a controlled activation identifier that transmits a signal upon contact with a target site of a body, wherein the signal is a conductive signal and wherein the controlled activation identifier comprises first and second electrodes that are configured to create a voltaic cell when in contact with a conducting fluid at the target site, wherein the voltaic cell supplies power to the controlled activation identifier, and wherein the controlled activation identifier is configured to transmit the conductive signal through tissue of to the body upon the first and second electrodes contacting the conducting fluid at the target site and the voltaic cell supplying power to the controlled activation identifier;
- and
- a pharmaceutically acceptable carrier.
A controlled activation ingestible identifier that transmits a signal upon contact with a conducting fluid present at a target site of a body, wherein the signal is a conductive signal and wherein the controlled activation identifier comprises first and second electrodes that are configured to create a voltaic cell when in contact with the conducting fluid at the target site, wherein the voltaic cell supplies power to the controlled activation identifier, and wherein the controlled activation identifier is configured to transmit the conductive signal through tissue of the body upon the first and second electrodes contacting the conducting fluid at the target site and the voltaic cell supplying power to the controlled activation identifier.
A system comprising:
- a controlled activation ingestible identifier that transmits a signal upon contact with a conducting fluid present at a target site of a body, wherein the signal is a conductive signal and wherein the controlled activation identifier comprises first and second electrodes that are configured to create a voltaic cell when in contact with the conducting fluid at the target site, wherein the voltaic cell supplies power to the controlled activation identifier, and wherein the controlled activation identifier is configured to transmit the conductive signal through tissue of the body upon the first and second electrodes contacting the conducting fluid at the target site and the voltaic cell supplying power to the controlled activation identifier;
- and
- a receiver for detecting a signal produced by the identifier.
A method comprising:
- administering to a subject a controlled activation ingestible identifier that transmits a signal upon contact with a conducting fluid present at a target site, wherein the controlled activation identifier comprises first and second electrodes that are configured to create a voltaic cell when in contact with the conducting fluid at the target site, wherein the voltaic cell is configured to supply power to the controlled activation identifier, and wherein the controlled activation identifier is configured to transmit the signal through tissue of the body upon the first and second electrodes contacting the conducting fluid at the target site and the voltaic cell supplying power to the controlled activation identifier, wherein the signal is a conductive signal transmitted to a body with first and second electrodes;
- and
- transmitting, by the controlled activation identifier, the conductive signal upon contact with the target site of a body.
Dependencies are inferred from the claim text.