Dynamic range improvement for mass spectrometry
AssigneeBruker Daltonics, Inc.
InventorShankar Telasang
Life of this patent
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Abstract
Embodiments of the present disclosure provide methods of controlling an ion detector to minimize false peaks when utilizing extended dynamic range techniques. In one exemplary example, methods of controlling an ion detector are provided, comprising the steps of: determining an electronic baseline signal of the ion detector; receiving one or more ion input signals at the ion detector; comparing the ion input signal to the electronic baseline signal; and multiplying the ion input signal by a selected compensation factor when the ion input signal exceeds the electronic baseline signal.
Claims9
A method of minimizing false peaks in a mass spectrometer having an ion detector that uses extended dynamic range techniques in forming a detector output signal, the method comprising the steps of:
- initially measuring a plurality of baseline electronic signals characteristic of the mass spectrometer;
- setting a Baseline threshold value equal to one of:
- Baseline threshold value=baselineaverage+(baselinemax−baselinemin) (i)
- where baselineaverage is an average of the plurality of baseline electronic signals, baselinemax is the maximum baseline electronic signal measured and baselinemin is the minimum baseline electronic signal measured, and
- Baseline threshold value=baselineaverage+SD (ii)
- where baselineaverage is an average of the plurality of baseline electronic signals and SD is a standard deviation of the average of the plurality of baseline electronic signals;
- receiving one or more ion input signals at the ion detector;
- comparing each ion input signal to the Baseline threshold value;
- and
- multiplying each ion input signal by a selected compensation factor when the ion input signal exceeds the Baseline threshold value while excluding those ion input signals which are below the Baseline threshold value from the multiplication, such that the output signal includes ion input signals that have been multiplied by the compensation factor and ion input signals that have not been multiplied by the compensation factor.
A non-transitory computer readable medium including software for controlling an ion detector of a mass spectrometer, the computer readable memory comprising logic configured for implementing the steps of:
- initially measuring a plurality of baseline electronic signals characteristic of the mass spectrometer;
- setting a Baseline threshold value equal to one of:
- Baseline threshold value=baselineaverage+(baselinemax−baselinemin) (i)
- where baselineaverage is an average of the plurality of baseline electronic signals, baselinemax is the maximum baseline electronic signal measured and baselinemin is the minimum baseline electronic signal measured, and
- Baseline threshold value=baselineaverage+SD (ii)
- where baselineaverage is an average of the plurality of baseline electronic signals and SD is a standard deviation of the average of the plurality of baseline electronic signals;
- receiving one or more ion signals at the ion detector;
- comparing each ion input signal to the Baseline threshold value;
- and
- multiplying each ion input signal by a selected compensation factor when the ion input signal exceeds the Baseline threshold value while excluding those ion input signals which are below the Baseline threshold value from the multiplication such that an output signal of the detector includes ion input signals that have been multiplied by the compensation factor and ion input signals that have not been multiplied by the compensation factor.
Dependencies are inferred from the claim text.