System and method for planning a neurosurgical operation

A system (10) for planning a neurosurgical operation, the system (10) comprising:

• an input (11) for receiving functional data and anatomical data (25) of a brain region (31), and
• a processor (12) configured to:
• analyze the functional data (25) to form a network representation (27) of functional connections, the network representation (27) comprising network nodes (32) and network connections (41) interconnecting the network nodes (32),
• map the network representation (27) of the functional connections and the anatomical data to a common coordinate system,
• determine an expected function loss associated with a simulated removal of one of the network nodes (32) or network connections (41) from the network representation corresponding to a simulated intervention, and to
• identify at least one of:
• critical network connections and critical network nodes based on the expected function loss.