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US 8,941,056 B2Granted
Mass spectrometer
AssigneeMicromass UK Limited
InventorsMartin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
Life of this patent
Estimating the term…
Abstract
A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitized. Arrival time and intensity pairs are calculated for both digitized signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
Claims27
A method of detecting ions comprising:
- outputting a first signal and a second signal from an ion detector, wherein said first signal corresponds with a signal multiplied or amplified by a first gain and said second signal corresponds with a signal multiplied or amplified by a second different gain;
- digitising said first signal to produce a first digitised signal and digitising said second signal to produce a second digitised signal;
- summing said first digitised signal with a plurality of other corresponding first digitised signals to form a first summed digitised signal;
- summing said second digitised signal with a plurality of other corresponding second digitised signals to form a second summed digitised signal;
- determining first summed intensity and arrival time, mass or mass to charge ratio data from said first summed digitised signal;
- determining second summed intensity and arrival time, mass or mass to charge ratio data from said second summed digitised signal;
- and
- combining said first summed intensity and arrival time, mass or mass to charge ratio data and said second summed intensity and arrival time, mass or mass to charge ratio data to form a final spectrum.
5 more elements
A method of detecting ions comprising:
- outputting a first signal and a second signal from an ion detector, wherein said first signal corresponds with a signal multiplied or amplified by a first gain and said second signal corresponds with a signal multiplied or amplified by a second different gain;
- digitising said first signal to produce a first digitised signal and digitising said second signal to produce a second digitised signal;
- combining said first digitised signal and said second digitised signal to form a combined digitised signal;
- summing said combined digitised signal with a plurality of other corresponding combined digitised signals to form a final spectrum;
- and
- determining intensity and arrival time, mass or mass to charge ratio data from said final spectrum.
3 more elements
An ion detector system comprising:
- a device arranged and adapted to output a first signal and a second signal from an ion detector, wherein said first signal corresponds with a signal multiplied or amplified by a first gain and said second signal corresponds with a signal multiplied or amplified by a second different gain;
- a device arranged and adapted to digitise said first signal to produce a first digitised signal and a device arranged and adapted to digitise said second signal to produce a second digitised signal;
- a device arranged and adapted to sum said first digitised signal with a plurality of other corresponding first digitised signals to form a first summed digitised signal;
- a device arranged and adapted to sum said second digitised signal with a plurality of other corresponding second digitised signals to form a second summed digitised signal;
- a device arranged and adapted to determine first summed intensity and arrival time, mass or mass to charge ratio data from said first summed digitised signal;
- a device arranged and adapted to determine second summed intensity and arrival time, mass or mass to charge ratio data from said second summed digitised signal;
- and
- a device arranged and adapted to combine said first summed intensity and arrival time, mass or mass to charge ratio data and said second summed intensity and arrival time, mass or mass to charge ratio data to form a final spectrum.
5 more elements
An ion detector system comprising:
- a device arranged and adapted to output a first signal and a second signal from an ion detector, wherein said first signal corresponds with a signal multiplied or amplified by a first gain and said second signal corresponds with a signal multiplied or amplified by a second different gain;
- a device arranged and adapted to digitise said first signal to produce a first digitised signal and a device arranged and adapted to digitise said second signal to produce a second digitised signal;
- a device arranged and adapted to combine said first digitised signal and said second digitised signal to form a combined digitised signal;
- a device arranged and adapted to sum said combined digitised signal with a plurality of other corresponding combined digitised signals to form a final spectrum;
- and
- a device arranged and adapted to determine intensity and arrival time, mass or mass to charge ratio data from said final spectrum.
3 more elements
Dependencies are inferred from the claim text.