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US 8,940,894 B2Granted
Aminothiazole compounds as kinase inhibitors and methods of using the same
AssigneeScience Incorporated
InventorsAlain Moussy, Philippe Reginault, Francois Bellamy, Anne Lermet
Life of this patent
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Abstract
The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula I: which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.
Claims3
A pharmaceutical composition, comprising:
- a polymorph form of the compound (VI), which remains dry at 80% relative humidity and thermodynamically stable at temperatures below 200° C.,
- wherein the polymorph form of the compound (VI) exhibits a single peak at approximately 237.49±0.3° C. when analyzed by differential scanning calorimetry, and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.