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US 8,940,893 B2Granted
Heteroaromatic compounds as BTK inhibitors
AssigneeBoehringer Ingelheim International GmbH
InventorsTodd Bosanac, Darren Disalvo, Joshua Courtney Horan, Shuang Liang, Renee M. Zindell
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Abstract
The present invention encompasses compounds of the formula (I) wherein the groups X and Cy are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
Claims10
A compound of the formula (I)
- wherein:
- Cy is carbocycle, heteroaryl or heterocycle, each is substituted by R1 and optionally substituted by halogen, halo C1-4 alkyl, C1-4 alkyl, oxo and C1-4 alkoxy;
- R1 is chosen from:
- L-Ar, C1-6 alkyl, —S(O)m—R3 and C1-6 alkoxy, each Ar, C1-6 alkyl and C1-6 alkoxy are optionally substituted by benzyl, halogen, halo C1-4 alkyl, C1-4 alkyl, R2—S(O)m—, —CN, —C(O)—N(R3)2 or C1-4 alkoxy;
- L is a linker chosen from a bond, O, >C(O), —(CH2)n—, —O—(CH2)n—, —N(R3)—, —N(R3)—(CH2)n—, —(CH2)n—N(R3)—, —C(O)—N(R3)—, —C(O)—N(R3)—(CH2)n—, —N(R3)—C(O)—N(R3)—, —N(R3)—C(O)—, —S(O)m—N(R3)—, R3—S(O)m—, and —N(R3)—S(O)m—, wherein the —CH2— in each L can have 1-2 hydrogens replaced by C1-3 alkyl, said C1-3 alkyl groups can optionally cyclize to form a C3-6 cycloalkyl ring;
- Ar is carbocycle, heterocycle or heteroaryl;
- X of the formula (I) is
- each X is optionally substituted by halogen, halo C1-4 alkyl, C1-4 alkyl and C1-4 alkoxy;
- R4 is
- each n is independently 1-4;
- each m is independently 0-2;
- each R2 and R3 are independently chosen from hydrogen or C1-4 alkyl;
- each R5 is independently chosen from hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylC1-4alkoxy, C1-4 alkylhydroxy, —(CH2)n-heterocycle and heterocycle each heterocycle optionally substituted by halogen, OH or R2—S(O)m—;
- each group defined above for Cy, R1-R5, and Y can be, where possible partially or fully halogenated;
- or a pharmaceutically acceptable salt thereof.
12 more elements
A compound chosen from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.