Process for producing benzo [b] [1,4] diazepine-2,4-dione compound
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsHisayuki Tsujimori, Shinichi Taira, Hirotaka Yukawa, Kaoru Abe
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Abstract
A process for producing a compound represented by formula (1), wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process includes deprotecting a protective group (R5) of a compound represented by formula (2), wherein R1, R2, R3 and R4 are as defined above, and R5 represents a protective group of a hydroxy group. The process is an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia.
Claims3
A compound represented by formula (2),
- wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, and R5 is a benzyl group that may be substituted by a group selected from the group consisting of a lower alkyl group, a halogen atom, a cyano group, a lower alkoxy group, a nitro group, a phenyl group and an acyl group.
A compound represented by formula (2A),
- wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, and R5 is a benzyl group that may be substituted by a group selected from the group consisting of a lower alkyl group, a halogen atom, a cyano group, a lower alkoxy group, a nitro group, a phenyl group and an acyl group.
Dependencies are inferred from the claim text.