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US 8,940,885 B2Granted
Cytotoxic nucleotides for targeted therapeutics
AssigneeWake Forest University Health Sciences
InventorWilliam H. Gmeiner
Life of this patent
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Abstract
The present invention provides a method of generating a nucleic acid, which specifically binds to an extracellular surface protein expressed by a cell of interest, and which nucleic acid comprises a compound of interest to be delivered to the cell of interest.
Claims7
A nucleic acid molecule, comprising:
- (i) a nucleotide sequence that specifically binds to an extracellular surface protein expressed by a cell of interest, wherein the nucleotide sequence comprises SEQ ID NO:1;
- and
- (ii) a cytotoxic nucleotide, wherein the cytotoxic nucleotide comprises poly-FdUMP;
- wherein the nucleic acid molecule ranges from about 30 nucleotides to about 150 nucleotides in length,
- wherein the poly-FdUMP comprises FdUMP[9] or FdUMP[10],
- wherein the poly-FdUMP is appended to the 3′-terminus of the nucleotide sequence, and wherein the poly-FdUMP further comprises a dC nucleotide appended to the 3′-terminus thereof.
3 more elements
A nucleic acid molecule consisting of SEQ ID NO:1 and FdUMP[9]dC appended to the 3′-terminus of SEQ ID NO:1.
Dependencies are inferred from the claim text.