Neutralizing antibodies against GDF-8 and uses therefor
AssigneesWyeth, MedImmune, LLC
InventorsGeertruida M. Veldman, Monique V. Davies, Kening Song, Neil M. Wolfman, Kristie Grove Bridges, Anne Field, Caroline Russell, Viia Valge-Archer
Life of this patent
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Abstract
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
Claims12
An isolated antibody or fragment thereof that specifically binds GDF-8, comprising:
- an antibody variable heavy (VH) domain comprising the first, second and third complementarity determining regions (CDR) from the VH domain defined by the amino acid sequence of SEQ ID NO:10 or SEQ ID NO:22;
- and
- an antibody variable light (VL) domain comprising the first, second and third complementarity determining regions (CDR) from the VL domain defined by the amino acid sequence of SEQ ID NO:12 or SEQ ID NO:24.
An isolated antibody that specifically binds GDF-8, comprising:
- two heavy chains, each comprising the VH region of the amino acid sequence of SEQ ID NO:22 and the heavy chain constant region from human IgG1;
- and
- two light chains, each comprising the VL region of the amino acid sequence of SEQ ID NO:24 and the light chain constant region of the amino acid sequence of SEQ ID NO:51.
Dependencies are inferred from the claim text.