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US 8,940,872 B2Granted
Antibody binding specifically to TDP-43 aggregate
AssigneeTokyo Metropolitan Institute of Medical Science
InventorsMasato Hasegawa, Tetsuaki Arai, Takashi Nonaka, Fuyuki Kametani, Haruhiko Akiyama
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Abstract
The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a method for detecting or diagnosing a TDP-43 proteinopathy lesion by using the antibody.
Claims11
A purified antibody that binds specifically to the following protein (a) or (b):
- (a) a protein consisting of an amino acid sequence in which at least one amino acid residue selected from the group consisting of amino acid residues 393, 403, 404, 409 and 410 of the amino acid sequence represented by SEQ ID NO:1 is phosphorylated;
- or
- (b) a phosphorylated partial peptide selected from the group consisting of amino acid sequences set forth in SEQ ID No:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, and SEQ ID NO:
- 11,
- wherein said antibody does not bind with an unphosphorylated amino acid sequence represented by SEQ ID NO:1 and with an unphosphorylated partial peptide selected from the group consisting of amino acid sequences set for the in SEQ ID NO:
- 2, SEQ ID NO:
- 3, and SEQ ID NO:
- 4.
11 more elements
Dependencies are inferred from the claim text.