Elastin based growth factor delivery platform for wound healing and regeneration
AssigneeThe General Hospital Corporation
InventorsPiyush Koria, Martin L. Yarmush, Yaakov Nahmias
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Abstract
The invention is based on the discovery of a potent growth factor delivery system by creating a fusion polypeptide that includes two portions: (i) keratinocyte growth factor protein, and (ii) an elastin-like peptide. This chimera can be administered directly to a wound site, accelerating recovery.
Claims12
A purified polypeptide comprising a keratinocyte growth factor (KGF) linked to an elastin-like peptide (ELP), wherein the polypeptide comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:2.
A method of producing a keratinocyte growth factor-elastin-like peptide (KGF-ELP) particle, the method comprising providing a polypeptide comprising a KGF linked to an ELP wherein the polypeptide comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:2, and incubating the polypeptide at a temperature of 30° C. to 60° C.
Dependencies are inferred from the claim text.