Pan-antiviral peptides
AssigneeNuovo Biologics, LLC
InventorsKent D. Miller, Billy S. Austin
Life of this patent
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Abstract
Methods for preparing viral neuraminidase inhibitors including antiviral peptides by specifically chemically modifying disulfide bonds in precursor molecules. A method of inhibiting viral neuraminidases by administering a viral neuraminidase inhibitor comprising an antiviral peptide prepared by the above methods and inhibiting the viral neuraminidase. Therapeutics for inhibiting viral neuraminidases, including effective amounts of viral neuraminidase inhibitors including antiviral peptides derived from selectively chemically modified disuifide bonds in precursor molecules, and present in a pharmaceutically acceptable carriers.
Claims24
A peptide-containing composition comprising an isolated peptide, wherein:
- (a) the peptide comprises the amino acid sequence of a native α-neurotoxin;
- (b) the cysteines normally involved in forming disulfide bonds are oxidized so they are unable to form disulfide bonds, such that none of the peptides in the composition have disulfide bonds;
- (c) the amino acids of the peptide are unmodified, except for lacking disulfide bonds;
- and,
- (d) the peptide has antiviral activity.
A method for treating and/or inhibiting viral infection in a patient in need of such treatment or inhibition, the method comprising administering a composition to the patient, wherein the composition comprises an isolated peptide, wherein:
- (a) the peptide comprises the amino acid sequence of a native α-neurotoxin;
- (b) the cysteines normally involved in forming disulfide bonds are oxidized so they are unable to form disulfide bonds, such that none of the peptides in the composition have disulfide bonds;
- (c) the amino acids of the peptide are unmodified, except for lacking disulfide bonds;
- and,
- (d) the peptide has antiviral activity.
Dependencies are inferred from the claim text.