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US 8,940,861 B2Granted
Variants of ancestral uricases and uses thereof
AssigneeGeorgia Tech Research Corporation
InventorEric A. Gaucher
Life of this patent
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Abstract
The present invention provides uricases and methods of their production and use in reducing the amount of uric acid in a subject. The present invention further provides methods employing a uricase of this invention in the treatment and/or prevention of hyperuricemia, gout, tumor lysis syndrome and/or hypertension in a subject.
Claims4
A uricase comprising at least one uricase subunit comprising the amino acid sequence of SEQ ID NO:8, wherein X1 is N;
- X2 is D;
- X3 is Y;
- X4 is K;
- X5 is D;
- X6 is D;
- X7 is M;
- X8 is Y;
- X9 is S;
- X10 is S;
- X11 is G;
- X12 is S;
- X13 is A;
- X14 is M;
- X15 is C;
- X16 is E;
- X17 is N;
- X18 is V;
- X19 is V;
- X20 is R;
- X21 is F;
- X22 is E:
- X23 is K;
- X24 is M;
- X25 is R;
- X26 is S;
- X27 is P;
- X28 is K;
- X29 is Q;
- X30 to is F;
- X31 is Q;
- X32 is H;
- X33 is G;
- X34 is D;
- X35 is E;
- X36 is T;
- X37 is V;
- X38 is R;
- X40 is L;
- X41 is L;
- X41 is E;
- X42 is F;
- X43 is G;
- X44 is E;
- X45 is S;
- X46 is P;
- X47 is Y;
- X48 is E;
- X49 is Y;
- X50 is M;
- X51 is D;
- and X52 is R and said uricase has enhanced uricolytic activity relative to a control uricase.
48 more elements
Dependencies are inferred from the claim text.