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US 8,940,857 B2Granted
Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
AssigneeMarina Biotech, Inc.
InventorsMohammad Ahmadian, Kunyuan Cui, Lishan Chen, Shu-Chih Chen, Michael E. Houston, Jr.
Life of this patent
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Abstract
A delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:11 or salt thereof. This invention is directed towards methods and compositions to administer a double-stranded ribonucleic acid to a mammal so as to effectuate transfection of the double-stranded RNA into a desired tissue of the mammal.
Claims9
A delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:
- 11 or salt thereof.
A composition comprising a delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:
- 11 or salt thereof, and a nucleic acid.
Dependencies are inferred from the claim text.