Pharmaceutical compositions with enhanced performance
AssigneeBend Research, Inc.
InventorsWalter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
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Abstract
Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
Claims10
A composition comprising a solid amorphous dispersion of a low-solubility drug having a solubility parameter δD and polymeric hydroxypropyl methyl cellulose acetate succinate (HPMCAS) having a solubility parameter δP, wherein the degree of substitution of acetyl groups (DOSAc) and the degree of substitution of succinoyl groups (DOSs) of said HPMCAS are as follows:
- DOSS≧0.02,
- DOSAc≧0.7, and
- DOSAc+DOSS≧0.9;
- and
- wherein (δD−δP)2<2.
Dependencies are inferred from the claim text.