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US 8,940,796 B2Granted
Phenylephrine liquid formulations
AssigneeWyeth
InventorsWilliam Bubnis, Stephanie Shield, Amanda Alley
Life of this patent
Estimating the term…
Abstract
An oral, aqueous-based, liquid pharmaceutical composition is provided. The composition comprises up to about 45% w/v glycerin and up to about 10% w/v sorbitol wherein the glycerin to sorbitol ratio is about 2:1 to 10:1.
Claims21
An aqueous oral pharmaceutical composition comprising:
- a). 0.05% w/v phenylephrine;
- b). 0.2% w/v sucralose;
- c). 25% w/v glycerin;
- d). 10% w/v sorbitol wherein the glycerin to sorbitol ratio is 2.5 to 1;
- and
- e.) wherein the composition is substantially free of phenylephrine degradants as measured under conditions of 60° C. and 60% relative humidity for approximately three weeks.
3 more elements
An aqueous pharmaceutical solution comprising:
- a). 0.05% w/v phenylephrine;
- b). 0.2% w/v sucralose;
- c). 25% w/v glycerin;
- d). 10% w/v sorbitol, wherein the glycerin to sorbitol ratio is 2.5:1;
- e.) 0.02% w/v brompheniramine;
- and
- f.) wherein the composition is substantially free of phenylephrine degradants as measured under conditions of 60° C. and 60% relative humidity for approximately three weeks.
4 more elements
An aqueous oral pharmaceutical suspension composition comprising:
- a). 0.05% w/v phenylephrine,
- b). 0.2% w/v sucralose,
- c) a viscosity modifying agent,
- d). 25% w/v glycerin,
- e). 10% w/v sorbitol wherein the glycerin to sorbitol ratio is 2.5:1;
- and
- f.) wherein the composition is substantially free of phenylephrine degradants as measured under conditions of 60° C. and 60% relative humidity for approximately three weeks.
4 more elements
Dependencies are inferred from the claim text.