US 8,940,783 B2 · Pheophorbide-α conjugates and their uses

Abstract

The present invention relates to a pheophorbide-α conjugate or its salt, solvate or hydrate. The pheophorbide-α conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells. Especially, the conjugate of pheophorbide-α (1) and doxorubicin shows higher fluorescence intensity at lower pH (cancer environment). Therefore, the present composition for photodynamic therapy (PDT) of cancers is also very useful in detecting cancers. Interestingly, the anticancer effects of the present composition are dually exerted with help of both the photosensitizer and the anticancer drug of the present conjugates.

Claims5

Dependent claims

A pheophorbide-α conjugate comprising:

(i) a first compound represented by the following Formula 1 and a second compound represented by the following Formula 2;
or (ii) a first compound represented by the following Formula 1 and a second compound represented by the following Formula 3:
or a pharmaceutically acceptable salt, or solvate thereof.

Dependencies are inferred from the claim text.

Facts

Application

13/563,974Filed 1 Aug 2012

Priority

KR 10-2012-000890130 Jan 2012

Published

US 2013/0210756 A115 Aug 2013

Granted

27 Jan 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 41/0076
Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or…:…
A61K 41/0071
Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or…:…
A61K 47/55
The modifying agent being an organic compound: the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire…
A61P 35/00
Antineoplastic agents

Pheophorbide-α conjugates and their uses

Life of this patent

Pheophorbide-α conjugates and their uses

Life of this patent

Abstract

Claims5